2.Early (non-ulcerated) Paget's disease of the nipple.
This cannot be differentiated clinically from adenomatosis of the nipple except by highly experienced surgeons. Immunophenotyping must be done on a biopsy specimen. Paraffin sections are to be treated with monoclonal antibodies against EMA and S100 using streptavidin biotin peroxidase system. If the sections treated for EMA reveal positive cytoplasmic staining of the cells by chromogen and those treated for S100 reveal no such staining, then this is early Paget's disease of the Nipple.
Early Paget's disease of the Nipple
Warty lesions of the scalp and skin
Is often present at birth and most often presents on the scalp as a warty nodule (Fig. 4). It frequently arises in association with a naevus, such as naevus sebaceus. It behaves in a benign fashion. Histologic sections show an exophytic/endophytic lesion creating a cystic space with a connection to the surface.The bulbous projections are loaded with plasma cells. The epidermis is papillomatous and acanthotic.
Syringocystadenoma Papilliferum of the scalp
Students' & Continuing Surgical Education